SCREEN Estier Optical Coherence Tomography System
3D Live-cell Imaging with NIR
SCREEN Estier is a stage-top optical coherence tomography (OCT) instrument that allows non-invasive analysis of the 3D structures including spheroids, organoids, tubular structures etc. As OCT provides an advantageous platform to visualise the in vitro dynamics of the 3D spheroids conveniently, it can be used as an alternative visualisation/monitoring method to obtain quantitative information about the morphological changes occur in 3D cell culture samples.
Optical coherence tomography (OCT) is already known as a versatile imaging method in the ophthalmological field, especially for examination of the retina. OCT uses low-coherence interferometry to produce a 2D cross-sectional image of optical scattering from internal tissue microstructures 3D images can then be constructed from these 2D images. OCT also allows imaging samples with a wide range of thickness (< 2 mm). OCT techniques, however, are unorthodox in the area of research and development because there are few accessible systems with stage-type implementation suitable for microplates and cell culture dishes. With Cell3iMager Estier SCREEN provides a solution to this problem.
FEATURES
- A label-free, non-invasive 3D tomographic imaging tool to facilitate drug screening (up to 1 mm thick)
- Detects necrotic regions and quantifies volume, internal cavities, tubular structures with impressive focus
- A cost-effective supplementary system to an existing imaging system
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