Electron diffraction is increasingly relevant for the structural characterisation of molecular compounds of pharmaceutical interest that are inaccessible to conventional X-ray methods. Crystal structure determination, polymorph identification and absolute structure determination can be performed on micro- or nanocrystalline particles within a powder, removing the need to grow large single crystals. Dedicated electron diffractometers enable high experimental throughput, particularly through automated data acquisition.
This webinar presents recent applications to pharmaceutically relevant compounds – the impact of optimising irradiation conditions, and how accurate structural refinements are achieved by accounting for multiple scattering, crystal mosaicity, morphology and bonding effects.
What You’ll Take Away
- What Holodiag does, and where 3D electron diffraction fits their workflow
- The basics of 3D electron diffraction (3DED)
- Real applications of 3DED to molecular, pharmaceutically relevant crystals
- How to deal with challenging samples (e.g. beam-sensitive samples)
Your Speaker
Emre Yörük (Holodiag), hosted by Eddy Martin (ELDICO Scientific). Emre earned his Ph.D. at the Néel Institute (CNRS) on low-dose electron diffraction for beam-sensitive materials, followed by postdoctoral research at the Institute of Physics in Prague on quantum-crystallographic refinement of electron-diffraction data, and at NYU Abu Dhabi on characterising flexible molecular crystals by electron diffraction.
ELDICO ED-1 Horizontal Electron Diffractometer
The world’s only dedicated horizontal electron diffractometer
Talk to Our Specialists About Your Application
Get in touch with Dr. Luke Nicholls by email below or call (01372) 378822.
About Holodiag
Holodiag is an expert CRO dedicated to pharmaceutical solid state and the crystallisation of small molecules. Founded in 2006 in Val-de-Reuil, France (now part of ICROM), it offers solid-form analysis; polymorph, salt and co-crystal screening; and crystallisation process development — and runs ELDICO’s ED-1 as part of that work.
About ELDICO
ELDICO Scientific AG – The Electron Diffraction Company – develops, produces, and sells dedicated electron diffractometers and offers structure elucidation services dedicated to industry. The company enables reliable structure determination for compounds that resist conventional analysis, delivering robust workflows built for reproducibility in regulated environments. ELDICO is based in Switzerland within the Basel life sciences cluster.
