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Sigray Chroma XRM-500 3D X-Ray Microscope
Highest absorption contrast XRM
Spatial resolution 0.5 µm
Introducing the Chroma XRM-500 system: this MicroCT with patented soft X-rays and up to five included target materials is designed for use in soft material and biological applications hence its categorisation as a BioCT.
- Highest absorption contrast laboratory x-ray microscope
- Enables imaging of challenging samples through a patented x-ray source design
- Submicron spatial resolution
- Achieve down to 0.5 µm spatial resolution and <300nm voxels
- Up to 5 detectors in a single system
- Optimise your field of view and resolution
The ChromaXRM features Sigray’s patented x-ray multi-colour source. Selecting the x-ray colour of the x-ray beam illuminating the sample can dramatically improve contrast to visualise details that would otherwise be missed, as clearly is seen in the images below comparing the ChromaXRM to the setup of the next leading XRM. Because of the high contrast, tomographies can be acquired at 10X the throughput for these challenging samples.
ChromaXRM achieves the highest spatial resolution available on the market at 500nm (0.5 µm).
Shown below are individual eggs resolved in the eggs sacks of a daphnia (water flea) specimen.
Up to 5 detector configuration options are available within the same system, enabling selection between multiple resolution and field-of-view settings analogous to a visible light microscope. Below is an example workflow in which detector modes are switched by software to zoom in on features of interest in an intact medicine container.
ChromaXRM’s patented x-ray source technology offers up to 5 user selectable X-ray target materials. Changing the X-ray target enables the user to optimise the X-ray spectrum for each application, thereby maximising contrast and throughput.
Each of the 5 x-ray spectra has its own peak x-ray energy and wavelength, similar to the concept of “colour” for visible light. For example, blue has a 450 nm wavelength while red has a 750 nm wavelength. Similarly, an x-ray source target made of Chromium will produce 2.3Å wavelength x-rays while a Copper target will produce 1.55Å wavelength x-rays.
Samples of different compositions and sizes are optimised when the illuminating x-ray is of the correct colour. Contrast and throughput can be maximised by >10X. Other XRM and microCT products on the market only offer an x-ray source with a Tungsten target, which offers good penetration but poor contrast on many challenging samples.
GigaRecon | Tomographic reconstruction software that pairs the fastest reconstruction times with an unmatched suite of features for achieving the best result every time. Reconstruction speeds of <45 seconds are achieved for 2048 x 2048 x 2200 datasets. GiagRecon provides the fastest iterative tomography reconstruction on the market, enabling high quality image reconstruction with 5X shorter data collection time, substantially accelerating tomography imaging time over conventional FDK reconstruction.
Sigray3D | Intuitive Acquisition
- Easy, intuitive software gets your team up and running in no time
- Click to align the sample and start measuring in seconds
- AI powered AutoPilot suggests the optimal settings for each sample
- Queue up to 20 samples with the automated Sample Handling Robot (SHR)
Above: GigaRecon provides high quality data with far fewer views required
Below: Sigray3D features an intuitive GUI for acquiring and measuring data
|Overall||Spatial Resolution||0.5 um with 40X objective|
|Minimum Voxel||275 nm|
|Source||Type||Sigray patented ultrahigh brightness sealed microfocus source|
|Voltage||20 – 60 kVp|
|Target(s)||Up to 5 targets.
Includes selection from Cr, Cu, Rh, W, Mo, Au, Ti, Ag.
Others available upon request.
|Detector(s)||Type||Up to 5 detectors. Includes LFOV detectors and high resolution detectors.|
|Camera||4MP deep cooled CCD|
|Visible Light Camera||16MP alignment camera|
|Software||Command and Control||Sigray 3D with Intuitive interface|
|Reconstruction||GigaRecon – fastest commercial CBCT reconstruction software|
|Offset Scans||Expands the horizontal FOV. Sigray software advantage|
|Helical Scan||Enabled for tall samples|
|AutoPilot||AI-assisted microscope operation for unsupervised acquisition|
|Linux Workstation||Interface is on a Windows workstation, while a separate robust Linux workstation controls the system. Advantageous for reliable 24-7 operation.|
|EPICS||Open-source software controls for maximum flexibility|
|Sample Size||50 x 50 mm diameter|
Life Sciences: Unstained Soft Tissue
X-rays are generally considered too energetic for soft tissue imaging. With the multi-spectral x-ray source on the ChromaXRM, a Chromium target can be selected to provide high quality, cellular resolution imaging of unstained biological soft tissue. Shown is an unstained liver sample with details down to hepatocytes.
Carbon Fibres and Low Z Materials
Carbon composites such as carbon fibre reinforced polymers and carbon paper represent some of the most challenging materials for 3D x-ray microscopes to image. The ChromaXRM provides excellent contrast and resolution for these samples, which enable straightforward segmentation for quantification. Image: Silicon carbide composite using the ChromaXRM. Contrast is substantially improved in comparison with W-based x-ray source results
Microstructural imaging during process development is critical in minimising time to market. ChromaXRM provides the ability to: quantify batch to batch variations in coating thickness, measure the distribution of API in formulation, and find cracks, voids and defects in tablets and pills. Choice of x-ray target in Sigray’s patented multi-spectral x-ray source improves contrast and throughput.